Pancreatic most cancers, which impacts about 60,000 People yearly, is without doubt one of the deadliest types of most cancers. After prognosis, fewer than 10 % of sufferers survive for 5 years.
Whereas some chemotherapies are initially efficient, pancreatic tumors usually change into immune to them. The illness has additionally confirmed tough to deal with with newer approaches comparable to immunotherapy.
Dr Steve Bigelsen
As a doctor who doesn’t observe different or complementary therapies, he’s conscious of the hurdles and arguments in opposition to recommending non-FDA accredited therapies and has a number of considerations himself. He believes that if these considerations are adequately addressed, we will fill a void that’s sorely missing between sufferers searching for one thing experimental to enhance their odds of survival (a lot of whom flip to inappropriate, futile different therapies) and the official scientific group who has actual hope to supply.
Pancreatic Most cancers and CA19-9 Tumor Marker Ranges
The graph under shows the check outcomes of a Stage 4 Pancreatic Most cancers affected person’s tumor marker ranges over time.
http://whsc.emory.edu/analysis/morningside/2019-conference-bios.html
The decrease the CA19-9, basically, the decrease the most cancers exercise. Inside days of including a repurposed drug cocktail to straightforward remedy, this affected person’s CA19-9 degree dropped like a stone, quicker than any of his Oncologists had seen with any such most cancers. The repurposed medicine he added have been Hydroxychloroquine and Paricalcitol – a type of injectable Vitamin D.
A traditional CA19-9 degree in somebody with out most cancers is under 35. This affected person with terminal Pancreatic most cancers noticed his ranges drop from 11,500 to under 35 in about three months. Nevertheless, he was not a median affected person; he was himself a doctor.
Dr. Stephen Bigelsen has taught at Rutgers College Medical Faculty as a professor in Allergy and Immunology. He’s a scientist and goes by the guide. He researched his most cancers and spoke to others who did extra particular analysis, and he didn’t settle for the consensus customary of care. As an alternative, he innovated, and he stays alive, some 5 years later, totally recovered from Pancreatic Most cancers. Like Ivermectin, Hydroxychloroquine and Paricalcitol are repurposed medicine. They’re deemed secure and efficient by the FDA for an additional illness, but utilized in most cancers after exhibiting scientific promise.
Like Ivermectin, the FDA and regulators hate the concept of repurposed medicine as a result of they’re getting used with out their permission or approval. Regardless, it’s authorized for physicians to prescribe them in the event that they consider, based mostly upon their data and expertise, it might assist and even save a life. Within the case of Dr. Bigelsen, it was his personal life that was saved.
QUESTIONS:
#1. Suppose nobody survives Stage 4 Pancreatic Most cancers utilizing customary remedy – the usual remedy of chemo/radiation/surgical procedure obtained by Alex Trebek, Patrick Swayze, and Michael Landon. Why do not we INFORM ALL most cancers sufferers that repurposed medicine are an possibility? Should you be a doctor like Dr. Stephen Bigelsen to get the repurposed cocktail? Most of us would by no means know even to ask.
Should a affected person detect a guide that explains this?
Only a few individuals come across repurposed medicine for most cancers. In consequence, 99.999% by no means get the kind of remedy that Dr. Bigelsen did. And he tells his story that getting right into a medical trial isn’t all that useful in the event you get just one drug, or solely get the placebo, or in the event you wait till the late levels when most cancers has returned in a resistant state.
Getting right into a medical trial in any case else fails in most cancers care is just too little, too late. It might assist the research, however it normally does little for the affected person. Dr. Bigelsen bought all of the medicine began by writing a prescription for himself, one thing most of us can’t do.
The repurposed drug cocktails MUST BE STARTED EARLY.
It’s the similar with COVID-19. The sooner one begins the Ivermectin, the higher. In India, complete households would start the Ivermectin the second one member of the family bought sick. This technique proved remarkably efficient, and it didn’t produce deaths, strokes, or blood clots.
What’s the level of all this? 1.9 million People contract most cancers every year, and 600,000 die from the illness. These numbers, for my part, will be diminished by 1/3 by the widespread adoption of repurposed drug cocktails. Sadly, the usual of care for many cancers stays Chemo/Radiation/Surgical procedure. I write so much in regards to the SAM cocktail, a mix of Statin/Aspirin/Metformin. Dr. Bigelsen writes about this as effectively.
Does hydroxychloroquine kill most cancers?
A 2017 assessment — which reviewed greater than 190 research investigating how chloroquine (CQ) and hydroxychloroquine (HCQ) have an effect on most cancers cells — describes how the malaria medicine might enhance tumor sensitivity to present most cancers therapies.
Primarily based on their findings, first research writer Ciska Verbaanderd, from the College of Leuven in Belgium, and her colleagues say that the medicine “deserve additional medical investigations in a number of most cancers varieties.”
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Whereas america has seen a fall in most cancers demise charges lately, the illness stays a big burden on public well being. Final 12 months, there have been greater than 1.6 millionTrusted Supply new most cancers circumstances recognized within the U.S. and greater than 595,000 most cancers deaths.
On condition that most cancers is more and more changing into immune to present therapies, there’s a determined have to uncover new methods to combat the illness.
Verbaanderd and colleagues consider that the medicine CQ and HCQ might assist on this combat.
CQ and HCQ are medicines used to stop and deal with malaria. They might even be used within the remedy of lupus and rheumatoid arthritis. A wealth of
For his or her assessment, Verbaanderd and colleagues analyzed the outcomes of greater than 190 animal and human research that assessed the results of CQ and HCQ on several types of most cancers.
Based on the researchers, the purpose of their assessment was “to tell additional analysis and trials on repurposing CQ and HCQ as anti-cancer brokers.”
The group uncovered proof to counsel that CQ and HCQ may very well be efficient for the remedy of various cancers, together with glioblastoma — which is a lethal mind most cancers — lung most cancers, and pancreatic most cancers.
“CQ and HCQ have been studied in a number of preclinical most cancers fashions,” write the authors, “and have demonstrated exercise on a number of cancer-supporting pathways and together with a broad vary of different therapies.”
“[…] Nearly all of these research have reported an improved therapeutic efficacy as in contrast with monotherapy with present anti-cancer medicine,” they add.
The assessment additionally signifies that each medicine are “secure and tolerable” as an anti-cancer remedy, although present proof means that HCQ may pose fewer unwanted effects.
Based on the group, their assessment highlights various mechanisms by which CQ and HCQ might assist to deal with most cancers.
Firstly, there may be proof to counsel that the medicine can inhibit autophagy, which is the method whereby cells devour their very own broken or pointless elements.
“Autophagic properties comparable to nutrient recycling can assist most cancers cell survival,” the authors observe. “Furthermore, key regulators of cell progress will be degraded and the DNA harm response will be suppressed via elevated autophagy.”
“Subsequently, inhibition of autophagy will be an attention-grabbing anti-cancer technique when most cancers cells begin relying on autophagy for survival.”
The assessment additionally revealed that CQ and HCQ can block the CXCL12/CXCR4 signaling pathway, which earlier analysis has related to most cancers development.
Moreover, there may be proof that CQ can stabilize a protein referred to as p53, which is a identified tumor suppressor, and it might additionally assist to normalize blood vessel dysfunction in tumors.
“The advantages of vessel normalization embody a lower in tumor hypoxia, diminished most cancers cell intravasation and metastasis, and a rise in chemotherapeutic drug supply and response,” the authors clarify.
General, Verbaanderd and colleagues consider that their research has highlighted the potential advantages of CQ and HCQ as a most cancers remedy, in addition to the mechanisms behind their anti-cancer properties.
The group notes that there are 30 medical trials presently investigating the results of CQ and HCQ in opposition to numerous most cancers varieties.
Primarily based on their assessment, the researchers conclude that these trials ought to give attention to the efficacy of those medicines, in addition to one of the best doses and strategies of administration.
References:
Case report: stage 4 pancreatic most cancers to remission utilizing paricalcitol and hydroxychloroquine along with conventional chemotherapy by Stephen Bigelsen: I’m a doctor specializing in Allergy and Bronchial asthma, who in July 2016, had tumors within the head and the tail of the pancreas with scattered peritoneal metastases and a CA19-9 of 11,575 U/mL. Working with physicians from Weill-Cornell and Johns Hopkins, I started remedy with gemcitabine and capecitabine, plus IV Paricalcitol (25 mcg 3x’s/week) and hydroxychloroquine (600 mg BID). These are each secure and cheap remedy choices which have proven success in pre-clinical fashions, part 2 human trials, and are available. I’ve now loved a full response with my newest CA19-9 of simply 15 U/mL and no proof of energetic illness on my most up-to-date CT scan.
Hydroxychloroquine in Beforehand Handled Sufferers With Metastatic Pancreatic Most cancers Hydroxychloroquine is accredited for the remedy of non-cancerous sicknesses comparable to rheumatoid arthritis and systemic lupus erythematous. Researchers within the laboratory have examined tumors from sufferers with pancreatic most cancers and have found that they’ve sure pathways contained in the cells that promote progress and survival of the tumor. Hydroxychloroquine might inactivate these pathways and leads to the demise of pancreatic most cancers cells.
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