For greater than a century, scientists have seen water has a wide range of uncommon properties that don’t match inside the basic mannequin of it being only a strong, liquid or gasoline.
Gerald Pollack constructed upon these observations, and finally decided that when a negatively charged floor is current, if an acceptable power supply can also be current (notably infrared — which is in every single place), the water will assemble itself into layers of offset hexagonal sheets with the system H3O2 that behave like a liquid crystal.
Word: Along with gentle, sound also can generate H3O2.
In my eyes, liquid crystalline water is a critically beneath appreciated space of science because it supplies a mechanism to elucidate lots of the unexplained mysteries of the physique (e.g., how accomplish that many fluids circulation inside it regardless of there being no identified pump to maneuver them) and a strategy to put phrases into a lot of what we incessantly observe inside the physique.
What Is Liquid Crystalline Water?
Liquid crystalline water has a major diploma of solidity, and can expel most issues from coming into it (e.g., polystyrene microspheres), together with the displaced hydrogen atoms (as it’s H1.5O not H2O). These displaced positively charged H atoms (henceforth known as protons), in flip assemble instantly exterior this lattice, thereby making a pH and cost gradient which will be measured.
In lots of instances, these H3O2 lattices will be huge — in favorable situations, Pollack and others have measured ones starting from 0.1 millimeters to 0.5 millimeters (100,000 to 500,000 nanometers or nm) in measurement. Cells depend upon this water, in order that they comprise a lot of surfaces from which the water can kind.
For instance, 20% of the cell is occupied by its cytoskeleton (a protein lattice which maintains its construction), and evaluation of high-voltage electron micrographs have proven that inside the cytoskeleton, over half of the water current is inside 5 nm of a floor it may doubtlessly kind H3O2 on (for reference a single H2O molecule is 0.27 nm in measurement).
For the reason that floor websites that water can construction on are so intently packed collectively in cells, it’s comprehensible why liquid crystalline water (additionally generally known as EZ water) can be a lot extra obvious to people observing residing cells beneath a microscope (which in actual fact is the place a lot of the early analysis on H3O2 originated from). This in flip raises one other query: why are cells designed to create a lot liquid crystalline water?
Word: An extended article describing the lengthy historical past of analysis into liquid crystalline water (H3O2) and its bodily properties will be learn right here.
Mysteries of the Cell
Within the earlier article, I mentioned a standard problem I observe inside science. When an incorrect mannequin is utilized to elucidate a pure course of, discrepancies between the mannequin’s predictions and actuality will inevitably seem.
One would count on that when this occurs, it will encourage these espousing the misguided mannequin to re-examine their mannequin, however as a substitute, since a lot has been invested into that mannequin, they as a substitute will denounce any challenges to it, and provide you with innumerable inventive methods to elucidate away every failure of the present mannequin.
Contemplate, for instance, the preliminary guarantees of the vaccines (for those who get two doses, you had been advised that you’d be fully immune, transmission would cease, and COVID-19 would quickly fade into reminiscence). For the reason that scientific trials for the vaccines had been fraudulent, not one of the vaccines’ guarantees materialized, and the COVID scenario as a substitute turned worse.
Nevertheless, as a substitute of healthcare authorities (and the medical group) admitting their mistake and switching to a distinct strategy for managing COVID-19, they doubled down on the vaccine mandates and moved the purpose posts again and again with reference to what mass-vaccination (and boosting) was truly supposed to perform.
Likewise, for mobile biology, our data of the cell is surprisingly primitive and the present fashions typically fail to elucidate what happens inside the mobile surroundings. Nevertheless, because the various fashions aren’t typically accepted by the scientific group, we have now been compelled to repeatedly patch the present fashions in order that they will considerably account for the innumerable mysteries of life.
At this level, I consider one of many key causes of this case is scientific analysis changing into distorted to prioritize specializing in discoveries that business can revenue from.
For instance, immunology has a slim deal with the elements of the immune system which will be focused by vaccination or proprietary medication, which in flip has left many different elements of the immune response uncared for (the immune system is often known as one of many least understood programs within the physique).
Equally, since pharmaceutical medication typically work by affecting receptors and channels in cells, mobile biology has adopted a narrow-minded deal with simply these elements of a cell.
In flip, the liquid crystalline section of water supplies a wide range of explanations for lots of the organic phenomena that the present fashions merely don’t adequately deal with. On this article, I’ll focus upon a couple of of them.
Word: A lot of what’s mentioned on this article is roofed in additional element inside these three books (equally, nearly all of the references for this text are sourced from these books, so I can’t repetitively cite them all through the article). If you happen to want to additional examine the topic your self, I might advocate studying these books (all authored by Gerald H. Pollack) on this order:
- The Fourth Section of Water: Past Stable, Liquid, and Vapor (2013)
- Cells, Gels and the Engines of Life: A New, Unifying Method to Cell Operate (2001)
- Section Transitions in Cell Biology (2008) — that is probably the most technical of the three
Mobile Integrity
One of many main puzzles of biology is the immense sturdiness that cells have. If you happen to take into account the basic mannequin — cells being luggage of liquid contained inside a fluid mosaic membrane, it must be easy for exterior forces to “pop” cells and have all of their contents spill out. But most often, cells preserve their integrity regardless of important stressors.
Cells can survive traumas, together with being guillotined in half, drawn and quartered (so particular elements will be remoted and labored with — similar to when performing in vitro fertilization), or shot stuffed with holes with electrical bullets, every of which one would count on can be ample to “pop” them. Nevertheless, in every occasion, mobile integrity of the remaining part persists.
Equally, if the membrane from a cell is eliminated, its inside contents stay in place relatively than quickly dispersing. It has additionally been identified for over 50 years that if muscle fibers lose their membranes, their practical means (making a contractile pressure) stays intact.
Three clues assist to elucidate these phenomena. The primary is that — as Pollack has proven — water droplets have a outstanding quantity of integrity, and like cells, will preserve their integrity (and subsequently fuse again collectively) if a micro-blade is used to guillotine them in half. The second is that Pollack has additionally proven water droplets comprise a major diploma of liquid crystalline water which possible is what confers their integrity.
The third is that the water molecules in cells predominantly exist inside gels, that are composed of that very same liquid crystalline water. Put in another way, because of this a cell’s stability is essentially a property of its water holding it collectively relatively than the exterior construction which encapsulates it.
One other vital side of mobile structure ought to now be thought-about. Because the situations for liquid crystalline water formation are current all through the cell (negatively charged hydrophilic surfaces and ambient infrared power), the cells ought to quickly be filling themselves with liquid crystalline water layers tons of of micrometers in thickness.
But, all through the cells, the surfaces are sometimes solely fractions of a micrometer aside. Because of this the construction of the cell relies upon upon the continuous formation of liquid crystalline water, however concurrently constrains that crystalline construction from rising to its full measurement.
Tensegrity
Classically in structure, buildings are created by having sturdy skeletons upon which the remainder of the construction rests. For instance, within the outdated days, we incessantly used stone pillars; these days, skyscrapers require metal superstructures to satisfy the wants of those buildings:
This mannequin typically doesn’t work inside residing organisms, as a result of life, not like these buildings, requires fast motion, and residing organisms merely can not produce strong constructions with the identical energy as metal beams. Nevertheless, another and extra advanced architectural mannequin has been developed which is incessantly utilized by those that embrace complexity inside their fashions.
Tensegrity (brief for tensional integrity), was a mannequin first put ahead by Buckminster Fuller. It posits that if a sequence of non-compressible constructions are linked collectively by a lattice of elastic connections (which may retailer rigidity when stretched), a a lot stronger construction is created.
It is because any pressure the construction receives can be equally distributed via every of these elastic connections relatively than concentrating on a single part (e.g., the stone pillar), and thus, a lot much less more likely to exceed the breaking level of any single structural part.
Fuller’s work subsequently impressed quite a few buildings to be constructed on the ideas of tensegrity. It is a basic image of him holding a tensegrity sphere he made:
Biotensegrity encapsulates the belief that this similar system additionally happens all through nature. For the human physique, at every degree of group, a linked tensile matrix is current that confers its stability.
One French hand surgeon, Jean-Claude Guimberteau, has likewise performed a outstanding job of demonstrating the presence of linked tensile constructions on the degree of fascia (a connective tissue current all through the physique many handbook therapists work with), via small (magnified) cameras positioned within the physique throughout minimally invasive surgical procedures:
Word: On the magnification scale used right here and in his different movies, liquid crystalline water will be immediately noticed coating these constructions. Additionally be aware its lubricating high quality that enables the constructions to slip previous one another. Lack of this lubrication seems to create a wide range of points inside the physique.
Because the years go by, there seems to be a larger consensus inside the holistic medical subject that biotensegrity is a sound mannequin for understanding the physique, and that linked networks of rigidity are current from the most important to the smallest ranges of the physique (e.g., the cytoskeleton is the elastic connecting unit inside every cell). Nevertheless, whereas this idea is incessantly mentioned, there are nonetheless two main unaddressed points with it, which I consider liquid crystalline water can clarify.
The primary is that in Guimberteau’s work, he had noticed that tiny vacuoles (enclosed compartments stuffed with water) all through the physique kind the essential incompressible unit that a lot of the physique’s tensegrity relies upon upon.
The second is that at a fair greater magnification inside cells, whereas a cytoskeleton is current that’s beneath rigidity, there may be nothing that may be seen which creates that rigidity (and it’s extremely debatable if the cell’s connections to the extracellular matrix suffice to create that rigidity). This issues as a result of the structural energy of a tensegrity system solely emerges when a construction’s elements are beneath rigidity.
Within the case of the previous, I consider that the microvacuoles are stuffed with liquid crystalline water (which can’t be compressed). Within the case of water droplets, Pollack concluded that the mutual repulsion between positively charged protons (pushed to the middle of the droplet by sheets of H3O2) creates an outwards pressure resisted by the liquid crystalline boundary of the droplet.
The stability between these two forces leads to the droplet assuming a spherical kind, and I consider the identical mechanism is at work within the microvacuoles all through the human physique.
Within the case of the latter, it is very important bear in mind how a lot enlargement is produced by proteins that create gels (many gels are over 99.9% water). Pollack, in flip, has proven that the liquid crystalline water that’s continually making an attempt to kind inside the cell is unable to achieve its full measurement resulting from proteins resisting the stretch that must happen had been the liquid crystalline gel to develop to its full measurement.
This occurs each on the degree of the cell (because the cytoskeleton stretches because the cell expands to its most measurement, till it can not permit additional enlargement to happen) and inside proteins all through the cell.
On the protein degree, the physique typically depends upon chemical bonds to be made between proteins to constrain the utmost enlargement that may happen in response to a gel forming. Moreover, proteins can alternate between a folded and an unfolded conformation (e.g., a helix vs. a coil), one thing typically decided by the strain utilized to the protein (such because the expansive stress of liquid crystalline water inside a gel).
There are a selection of significance penalties of this conformation change which can be mentioned later on this article (e.g., for the physiology of muscle tissues). Moreover, many different elements of the physique additionally seem to depend on liquid crystalline water:
“Learning collagen, Melacini et al. famous the significance of water in stabilizing its triple helix crystalline construction. They discovered that water inside the collagen helix types a “semi-clathrate-like construction that surrounds and interconnects triple helices within the crystal lattice.”
Water inside the matrix of bone is likewise extremely structured, a structuring that has been discovered related not solely with natural macromolecules similar to collagen and proteoglycans, however with the mineral surfaces as effectively. Water, in actual fact, appears to play a foundational function in orienting mineral nanoparticles into parallel preparations inside the bone matrix, offering this orientation even within the absence of natural molecules.”
On a regular basis Gel Expansions
Many applied sciences we’re conversant in (e.g., diapers) depend on hydrogels which may increase right into a semisolid construction which retain water. Equally, we are able to immediately observe that many bigger processes inside the physique are additionally dependent upon water’s tendency to assemble into the bigger liquid crystalline constructions.
As a result of the conventional structure of protein’s cross-linking habits limits how a lot gels can increase (because the proteins which would want to separate to accommodate the rising gel are prevented from doing so by cross hyperlinks between them), when tissue or protein is broken, this limitation will be partially eliminated. Consequently, it may be seen on a microscopic scale that human tissue will swell and increase when it’s broken.
Likewise, Pollack has argued that that is most probably what occurs if you expertise a musculoskeletal trauma. In Pollack’s proposed mannequin, the preliminary gel formation additional expands the present tear, and this progressive enlargement of liquid crystalline water finally results in seen swelling.
On a bigger scale, one of many main engineering challenges for the physique is having weight-bearing joints just like the knees be capable of preserve their vary of movement with out changing into broken by the continuous friction they expertise each day.
A outstanding attribute about liquid crystalline water is that, supplied the floor from which it types stays intact, liquid crystalline water will be destroyed after which reform, together with its virtually frictionless floor, again and again.
Due to this, the liquid crystalline water finally ends up being the part which absorbs the stress skilled by wholesome joints, and supplied the joint is wholesome, this water can immediately regenerate from that stress. Together with this regenerating layer of negatively charged liquid crystalline water, on the very heart of the joint, there’s a pocket of positively charged protons which repel from one another and create an expansive stress (like what’s seen in a water droplet).
For the reason that joint capsule seals this area, these protons are unable to flee and thus successfully perform like repelling magnets (e.g., take into account a maglev practice) that resist the load of the physique and preserve the central house inside the joint.
One of many issues I take into account probably the most compelling about Pollack’s mannequin for the joints is the particular high quality of synovial fluid contained in the knee joint. Whenever you view it on a digital camera throughout an arthroscopic surgical procedure, diffusion inside it’s visibly slowed, whereas for those who immediately extract it (e.g., throughout a knee aspiration), you may inform that it has a a lot thicker and gelatinous high quality, one thing I’ve realized to affiliate with the presence of liquid crystalline water.
Pollack likewise argues that his mannequin suggests EZ (liquid crystalline) water’s habits resembles that of a gelatinous egg white which is semisolid when left alone, but in a position to circulation in response to an imposed shear pressure.
Mobile Gradients
Word: A “gradient” describes a distinction within the focus of issues in two completely different areas. This might embody electrical fees (i.e. batteries rely upon gradients), electrolytes, or temperatures — and plenty of gradients present an simply harvestable supply of power.
The prevailing paradigm of physics asserts the next:
- The pure state of issues is to be disordered and evenly blended.
- Anytime you make one thing develop into extra ordered (e.g., forming a crystal or making a gradient between two areas), power should be expended to create that ordering.
- When an ordered construction turns into disordered, power is launched within the course of which may generally be harvested (e.g., combusting wooden in a wooden range to warmth our properties).
- Anytime power is launched from one thing, for those who try to seize and retailer that power, some power will all the time be misplaced.
These legal guidelines, in flip, are used to refute the likelihood that any sort of “free-energy” system can exist, such because the exclusion zone (EZ) water system Pollack has proposed the place quite a few harvestable gradients are created. Sadly for the present paradigm, biology typically seems to violate these legal guidelines, as it’s frequently transferring in the direction of a extra ordered state relatively than the disordered state the present paradigm predicts.
The present decision for this paradox (which received a Nobel prize) is that residing organisms perform as “dissipative constructions,” which change the order in massive quantities of ordered elements they accumulate from their surroundings in return for imparting order to their very own disordered contents.
Though to some extent this permits the present paradigm to maintain itself, I don’t consider it’s solely correct as water, via its liquid crystalline construction, has the power to retailer radiant power that passes via it and convert that power to order the physique can then make the most of.
The Sodium Potassium Gradient
One of many issues residing cells are well-known for doing is concentrating potassium inside themselves and reciprocally expelling sodium. For the reason that focus inside and outdoors cells differs, a gradient exists, which, by the present legal guidelines of physics ought to attempt to equalize itself and quickly disappear.
Since this doesn’t occur, the present mannequin has argued that the mobile membrane prevents the passage of most however not all sodium and potassium (thereby inhibiting the gradient from equalizing itself) and that sodium potassium pumps on the mobile membrane exist which continuous swap sodium contained in the cell for potassium exterior the cell.
As a result of this change is so important to sustaining the well being of the cell, a big focus in mobile biology is positioned on the significance of the sodium potassium change pump. Sadly, there are three elementary issues with this mannequin (the proof of every of those and extra is offered by Gilbert Ling right here):
- The mathematics doesn’t add up — the present sodium potassium pumps merely shouldn’t have the capability to counteract the pure undoing of the sodium and potassium gradients. For instance, in muscle cells, sustaining the sodium potassium gradient with pumps requires between 4 to 30 occasions the whole obtainable power within the cell.
- Cells are in a position to preserve a gradient with a wide range of different undesirable elements they expel (e.g., micro organism expelling antibiotics) and to elucidate these phenomena, increasingly pumps are recognized to attempt to help the mannequin. It is a drawback as a result of it’s unlikely that cells have the capability to concurrently maintain so many various pumps.
- Ling took frog muscle cells whose surroundings was altered in order that they had been fully starved of power (which is required to function the sodium potassium pump). Regardless of this, the gradient was maintained.
This then begs the query of what might be creating this gradient? Ling made the next observations:
- The gradient was maintained if the cell membrane (the place these pumps reside) was eliminated.
- Producing a membrane with sodium potassium pumps that didn’t comprise a cytoplasm (the within of a cell) resulted within the gradient quickly disappearing from with the membrane.
This implies that the gradient is a property of the cell cytoplasm relatively than the mobile membrane. Apparently, the equivalent property has been present in synthetic gels, which just like the cytoplasm, additionally generate massive quantities of liquid crystalline water:
“We present that the gel barrier is ready to preserve a secure separation of ionic options of various ionic strengths and chemical compositions with none pumping exercise. For the Na+ /Ok+ focus gradient sustained throughout the barrier, a adverse electrical potential develops inside the Ok+ -rich facet. The scenario is paying homage to that within the cell.
Moreover, additionally the advective circulation of water molecules throughout the gel barrier is restricted, regardless of the gel’s massive pores and the osmotic or hydrostatic stress gradients throughout it.”
This focus phenomenon has additionally been noticed by different authors:
“Proof for such accumulative condensation was produced virtually a century in the past when Bungenberg de Jong in 1932 confirmed that even dilute options of polymers, when shaken, coalesced into droplets-then known as coascervates-in which the natural matter turned extremely concentrated. The polymer focus in such droplets may exceed the focus within the surrounding tub by as a lot as 10,000 occasions.
When positioned in sure dyes, the droplets turned progressively extra coloured, the depth typically many occasions exceeding that of the encircling answer. Thus, gel droplets had the capability to pay attention sure solutes, because the cell concentrates potassium.”
Since gels independently reveal lots of the inexplicable traits of cells, it’s thus affordable to conclude they could share a mechanism for producing the sodium potassium gradient noticed all through biology.
Obstacles
One main problem for all cells is holding undesirable issues out. Classically, we view the method of pathogenic substances coming into cells as being a product of their interplay with matching receptors on the cells (a world view which I consider is emphasised by medical science as a result of medication will be developed to disrupt this course of). I, in flip, consider that this exclusion course of by the cell is closely influenced by current fees, zeta potential and liquid crystalline water.
As a result of liquid crystalline water can for probably the most half solely kind on negatively charged surfaces (the identical means that water molecules every expel half a hydrogen atom and thereby maintain a internet adverse cost as a result of misplaced hydrogens), virtually each floor within the physique (and plenty of different pure programs) is coated with a adverse cost.
Since colloidal stability (which governs the habits of most fluid programs) largely relies upon upon the mutual repulsion created by equivalent fees, most pure colloidal programs make the most of adverse fees to stay dispersed and solely clump collectively if extreme constructive fees are current (likewise most strategies of restoring zeta potential function on this precept).
Pathogenic organisms typically impart constructive fees to their surroundings (similar to via micro organism decarboxylating the adverse fees of amino acids inside proteins). This causes proteins and cells contained in the physique to start clumping collectively (the malaria parasite is especially good at doing this), which each prevents the immune system from getting access to the microbes and will increase the microbe’s means to realize entry to the cells.
One of many notably fascinating observations made by the unique proponent of physiologic zeta potential was that bacterial and viral infections (I consider this was probably the most studied with influenza) would create a constant degradation of the physiologic zeta potential. This supplies an evidence for why viruses like influenza will be a lot extra harmful for the aged.
Somebody with a wholesome zeta potential can tolerate a minor impairment of their colloidal stability (they’ll simply really feel a bit unwell), however for somebody who already has an impaired zeta potential (which is a quite common consequence of getting older), that discount will be ample to go a crucial threshold the place extreme sickness onsets.
One of many earliest distinguishing traits of COVID-19 to me was that many sufferers developed scientific indicators suggesting extreme zeta potential disruption, one thing I had not seen with another respiratory virus. A key motive I used to be involved in regards to the spike protein lengthy earlier than the vaccines entered the market, was as a result of I had recognized it because the possible perpetrator for this zeta potential disruption.
This was resulting from it being a novel part of the SARS-CoV-2 virus (it differed from that of SARS-CoV-1) that was current on the floor of the virus and which had an unusually excessive constructive cost density. It has since been proven that the spike protein immediately induces clumping of crimson blood cells, possible resulting from its cost distribution having the potential to create a major disruption of physiologic zeta potential.
One of many fascinating feedback I’ve repeatedly seen acknowledged by each people who’ve taken protocols to enhance their physique’s manufacturing of liquid crystalline water and people who’ve performed the identical for bettering their zeta potential, is that they hardly ever get sick.
This might doubtlessly imply both that the signs of infections are far more minor if these physiologic parameters are already in good well being (e.g., because you don’t go a crucial zeta potential threshold), or as a result of they immediately stop cells from changing into contaminated by pathogens.
As many components which positively have an effect on one of many parameters typically have an effect on the opposite (e.g., earthing improves zeta potential and promotes the expansion of liquid crystalline water within the physique), it’s a bit exhausting to say which impact in the end predominates, and a terrific deal of my analysis on this matter was primarily based on making an attempt to reply that query.
Word: The strategies of restoring zeta potential and rising liquid crystalline water inside the physique are mentioned additional right here.
On this article, we overview a number of the proof supporting that barrier speculation. The earliest I got here throughout was from the work of Viktor Schauberger (1885-1958), who believed it was critically vital for water to journey in a vortexing sample, one thing as mentioned within the earlier a part of this sequence, has been proven to extend the presence of liquid crystalline water.
One of many many discoveries made by using vortexing programs primarily based on his design for water provides was that it diminished the expansion of micro organism inside the water system (e.g., on the within of pipes).
Different analysis has immediately discovered that the presence of liquid crystalline water prevents the expansion and invasion of micro organism, similar to this examine:
“In a take a look at carried out with E. coli, cells progressively penetrated EZ [liquid crystalline water] over 2 days. Moreover, EZ-bearing Nafion had 80% much less biomass accumulation of E. coli over 2 days in comparison with an EZ-less, hydrophilic, clean aluminum oxide floor. This implies that EZ could signify the primary line of protection, spatially and temporally, towards micro organism approaching sure hydrophilic surfaces.
These findings may have vital implications in creating biofouling-resistant materials surfaces for purposes delicate to bacterial attachment and biofilm formation.”
And this examine:
“Silk sericin is a globular protein whose resistance towards fouling is vital for purposes in biomaterials and water-purification membranes. Right here it’s proven how sericin generates a water-exclusion [liquid crystalline] zone which will facilitate antifouling habits. Negatively charged microspheres had been used to imitate the floor cost and hydrophobic domains in micro organism.
Immersed in water, sericin fashioned a 100-µm-sized exclusion zone (for micron-size foulants), together with a proton gradient with a lower of >2 pH-units. Thus, when involved with sericin, water molecules close to the floor restructure to kind a bodily exclusionary barrier that may stop biofouling.
The decreased pH turns the aqueous medium unviable for neutrophilic micro organism. Due to this fact, resistance to biofouling appears explainable, amongst different components, on the premise of water-exclusionary phenomena.”
Many tissues depend upon the presence of liquid crystalline water lining them, and that is possible not less than partly, as a result of protecting barrier they create. Inexperienced and Otori in 1970, for instance, discovered exclusion zones roughly 350 μm deep extending from the cornea, and likewise from contact lenses (it’s vital to guard the attention from injury, and liquid crystalline water capabilities as a clear, well-lubricated barrier, qualities each crucial for the eyes).
Pollack, roughly 15 years in the past, additionally discovered equivalent outcomes (the presence of liquid crystalline water) subsequent to polyNIPAM, the gel used to manufacture contact lenses.
Probably the most vital tissues within the physique for offering a protecting (however well-lubricated layer) is on the endothelial lining of the blood vessels. There, massive quantities of blood creating important shear forces continually go over the blood vessels. Thus far, Malcom Kendrick has famous that the areas of circulation which expertise the best shear forces are the most probably to develop the power injury which finally results in coronary heart illness.
The protecting coating of the endothelium, the glycocalyx, is structured (resulting from its excessive sulfate content material) to create massive quantities of gel (liquid crystalline water) round it and thus defend the endothelium. Moreover, a skinny layer that blood cells can not enter is understood to immediately line the partitions of even the smallest blood vessels.
Equally, researchers in 2000 noticed a 0.4-0.5μm thick gelled layer of water lining the endothelium of wholesome capillaries (the smallest blood vessels within the physique), and this lining excludes a wide range of completely different substances from reaching the endothelium.
Formally, the vaccine spike protein can not have an effect on the endothelium as a result of it lacks a practical ACE2 binding area (whereas the COVID-19 virus has a practical one via which it then enters the cell).
Though that is the case, there are many different methods that the spike protein can nonetheless connect to the endothelium (e.g., the spike protein can nonetheless connect to the receptor, it immediately binds heparin within the glyocalyx, and whether it is produced from contained in the endothelium by the vaccine, it has successfully entered the endothelium).
Since autopsies of people suspected to have died resulting from vaccination have revealed profound injury to the endothelial layer, this supplies sturdy proof that the spike protein in a technique or one other has the power to penetrate the usually protecting barrier there.
Many have suspected that that is partly as a result of extremely constructive cost that the spike protein (and the generally positively charged elements of the lipid nanoparticles) carries, as these constructive fees can penetrate the liquid crystalline water barrier defending cells just like the endothelium.
I consider it might even be as a result of spike protein’s disruption of zeta potential, as different states related to elevated blood viscosity (e.g., uncontrolled diabetes) are identified to injury the endothelium and speed up the development to heart problems.
Section Transitions
Though liquid crystalline water is critical for all times, an excessive amount of of it may also be problematic. For instance, if the complete cell was lined with gel-state water, it will not be doable for a lot of issues that wanted to enter the cell to enter.
To resolve this drawback, areas of constructive cost exist within the membrane (e.g., Pollack argues that it is a key motive for the position of metallic ions inside the cell membrane), which stop liquid crystalline water from forming over the world and thus create an open passage for water to journey via.
Word: Though we’re taught to think about the cell as a fluid mosaic of phospholipids with proteins right here and there, roughly 50% of the cell membrane is often composed of proteins (and it will possibly generally be much more).
Normally, nonetheless, the physique depends upon with the ability to rework water between its gel (liquid crystalline) state and a sol (bulk water containing colloidal suspensions) state as wanted. Nevertheless, whereas recognition of the basic significance of section modifications in mobile biology has step by step elevated over the past 70 years, nearly all of the scientific subject continues to be wedded to the fluid mosaic speculation, which believes that the mobile membrane is all the time a liquid.
Briefly, gels (each pure and artificial ones) sometimes have a temperature (its transition level) the place the gel will endure a fast transition from one state to the opposite (defined additional right here). So far as I do know, in all instances, the warmer temperature will correspond to the sol state (H2O water with suspended colloids) and the colder one will correspond to the gel state (H3O2). Moreover, elevated stress can even promote the gel state:
“Organic exercise virtually universally requires that membranes be of their fluid state; in lots of instances, simply above the transition level.”
Gels all through the physique, in flip, are designed to have a section transition level close to the conventional temperature of the physique. This may occasionally clarify why most mammals and birds preserve their temperature between 35°– 42°C (95°– 107.6°F; the conventional temperature for people is 37°C or 98.6°F), an in any other case curious truth given how a lot their our bodies and environments differ (e.g., a tiny fowl within the desert vs. a blue whale).
Moreover, this temperature extends past warm-blooded animals. A tuna fish, when lively, maintains the temperature of its physique at 30°C or 86°F (the ocean is way colder) whereas many reptiles preserve their physique temperature close to 40°C or 104°F (by doing issues like searching for out the solar). Many bugs additionally can not fly till they’ve warmed as much as an analogous vary of temperature (e.g., 38°C or 100.4°F for bumblebees).
Equally, the section transition level is closely influenced by the supplies that the gel builds from (e.g., elements of the cell membrane). Chilly-blooded animals in flip have been noticed to vary the composition of their cell membranes in response to their surroundings.
In a single experiment, Calotes versicolor (the frequent backyard lizard), had been acclimatized to 16°, 26°, and 36°C (60.8°, 78.8°, and 96.8°F) for a interval of thirty days. The lizards exhibited dramatic modifications within the focus of main phospholipids (elements of the cell membrane) similar to phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, cardiolipin, and sphingomyelin.
Temperature acclimatization has additionally been noticed to fluctuate the lipid composition of carp muscle microsomes together with carp blood cells, and seasonal variation has been noticed within the lipid composition of brains of rainbow trout.
As soon as the gel is held close to its transition temperature, it’s then relative simple to vary precisely the place that transition temperature is so water will be stored within the acceptable section for the present physiologic wants. That is primarily performed inside the physique by altering the electrolyte composition of the world, as sturdy cations (positively charged ions) destroy gels, whereas sturdy anions (negatively charged ions) reinforce them.
So far as I can inform, the consequences of those ions correlate to the excessive valence (cost) anions (-) that the majority successfully help physiologic zeta potential and people excessive valence cations (+) which most successfully destroy it.
The first cation ingredient which the physique makes use of to shift the transition temperature to be able to destroy gels is calcium (Ca). For instance the impact of calcium graphically (be aware how a sudden crucial threshold of Ca focus is reached):
These outcomes additionally confirmed how the upper valence cations, Ca2+, trigger smaller gels to kind relative to low valence cations Na(1)+.
As soon as you set all of this collectively, you successfully get a scenario like this inside the cells which permits small secretions of calcium there to shift its water from a fluid to a gel state.
Conversely, if the physique can disperse the gels, it additionally wants a strategy to recreate them. The first sturdy (excessive valence) anion it makes use of to construct them are the phosphates in adenosine triphosphate (ATP).
After we take into account this various perform of ATP, we should always take into account a number of the concepts first proposed by Ling (see 8.4 on web page 178). They recommend that a lot of the power obtained from ATP arises not from the power inside its bonds being damaged, however relatively from it inducing water to kind a liquid crystalline construction. In essence, a lot of the power generated from ATP in the end arises from the radiant power which triggers these polymerizations (gels).
Section transitions are quite common in mobile biology, and whereas the sector doesn’t place a heavy emphasis on their significance, Pollack’s central argument in his first two books is that section transitions are crucial to elucidate many capabilities of the cell.
Word: After I later mentioned my articles with Pollack, he knowledgeable me that the principle oversight together with his earlier analysis was that that they didn’t but know that the gels had been negatively charged, which in flip explains a wide range of the consequences they create (e.g., {the electrical} impulse of nerves).
Increasing Gels
One of many major makes use of for gels inside the physique is from them to quickly increase and create results from that enlargement. For instance, cells incessantly excrete small spheres (referred to as vesicles) containing vital elements, which upon exiting the cell quickly increase. Remoted mucin-producing vessels for instance endure a 600 fold enlargement in 40 milliseconds.
Previous to exiting the cell, the inner elements of the vesicle are cross linked collectively by Ca2+ (bear in mind, greater valence cations, via crosslinking gel proteins, will restrict gel formation whereas monovalent cations like sodium as a substitute are likely to increase them).
As soon as secreted from the cell, Ca2+ is eliminated and the gel quickly hydrates within the Na(1)+ answer surrounding every cell. Conversely, gels won’t quickly increase in distilled water, and it has been noticed that liquid crystalline water’s formation can also be diminished inside deionized water.
Word: Some vesicles make the most of native environmental components to vary their section. For instance, histamine is a monovalent cation (cost of +1) at a impartial pH, however turns into a divalent cation (cost of +2) in an acidic pH. Researchers had been in a position to present that histamine in an acidic surroundings (resulting from its excessive valence state), causes shrinking of mast cell granules, whereas histamine in a impartial surroundings permits their enlargement.
Muscle Physiology
Most of the most typical issues for which sufferers hunt down physicians originate from the muscle tissues. Due to this, I’ve checked out loads of alternative ways to deal with these points. In flip, I’ve discovered fairly a couple of that persistently work however I can not clarify why as the present mannequin of muscle physiology can not present an evidence.
One of many main issues with drugs (and sometimes science) is what I time period the “mechanistic entice.” Briefly it implies that if there may be not a mechanism to elucidate why one thing works, then it’s assumed to be a hoax and thought to not truly work. I feel this compulsive want for a mannequin is sort of silly, particularly since lots of the fashions we make the most of to elucidate why medication work, don’t truly make sense.
Equally, there are numerous instances of a beforehand accepted mannequin for a drug’s mechanism that was discarded and changed with one other, and I do know of many extra examples the place an unorthodox mannequin seems to offer a a lot better rationalization for the mechanism of a remedy.
Word: This additionally holds true for a lot of various non-drug therapies.
Sadly, it’s almost not possible to have the FDA (or many conventionally educated physicians) be open to contemplating a remedy for analysis until a biochemical mechanism for it’s proposed. I consider it is a reflection of the very fact pharmaceutical medication, as they’re designed to focus on sure enzymes within the physique, match into our inflexible mechanistic paradigm, whereas therapies with a broad spectrum of motion can’t be linked to a particular biochemical receptor nor as simply profited from.
Given all of this, I used to be overjoyed to find via Pollack that many elements of the present mannequin for muscle physiology don’t make sense, and the anticipated outcomes of the mannequin don’t happen when rigorous experiments on muscle tissues are carried out:
Nevertheless, another mannequin for muscle physiology additionally exists. As we take into account it, we should always take into account that muscle tissues are acknowledged to solely be able to contracting. Within the situations the place one thing within the physique wants to elongate, that is completed by having a muscle in the correct place shorten, and resulting from its place, create a lengthening someplace else via doing so (e.g., the triceps within the arm).
From Pollack’s work, I spotted that whereas muscle tissues can solely create pressure throughout a contraction, that is truly a results of the very fact their elements can solely forcefully lengthen.
Pollack’s mannequin relies on the commentary that relaxed muscle tissues comprise a considerable amount of structured water, whereas contracting muscle tissues primarily comprise water not in a semisolid gel state. Since it’s identified that muscle firing follows the nerve sign directing calcium (Ca2+) ions to enter the muscle, this means a calcium induced section change could underlie the method.
Conversely, it is usually identified (from the experiment beforehand described within the gradient part) that whereas muscle cells which have been minimize open can retain their potassium to sodium gradient whereas in a salt answer, the elements that lack ATP are unable to.
This implies that ATP is critical for the liquid crystalline state of water to be current, because it excludes sodium ions from coming into the muscle cells. Equally, it is usually identified that with out ATP, muscle tissues will stay caught within the contracted kind and be unable to elongate, one thing that happens shortly after dying (termed “rigor mortis”).
Word: One of many compelling anecdotal tales I’ve heard over time is that when severely vaccine-injured kids die (e.g., these with lifelong debilitating autism) rigor mortis units in a lot quicker for them. Those that noticed this prompt that these kids had a power power deficit, and their our bodies had been struggling to make sufficient ATP to get by. I feel that is very doable, but it surely may be indicative of poor zeta potential.
I think this may also be seen with different power debilitating diseases, however I’ve not interacted with the individuals who would have noticed if it did in actual fact happen.
Pollack additionally noticed that muscle modifications in response to environmental components adopted a well-known crucial threshold being handed. This additionally appeared to recommend to Pollack {that a} section change was occurring inside the muscle tissues.
So what’s Pollack’s mannequin? The muscle tissues fibers are designed to kind massive gels round them, and as liquid crystalline water inside them expands, it stretches the uncoiled proteins within the fibers into helixes (till protein cross hyperlinks stop additional stretching). When the muscle must contract, calcium ions enter the muscle, eliminating the gels, and the proteins now not being lengthened elastically snap again to their unique uncoiled configuration.
To ensure that the gel to rebuild, ATP is required to interrupt the cross hyperlinks created by calcium and thereby set off a section shift that reconstructs the gel.
Thus, the energy of a muscle is a product of the potential power created by liquid crystalline water’s storage of radiant power being launched. Or put in another way, the energy of muscle tissues truly lies of their means to spontaneously lengthen and explains why many efficient muscular therapies I’ve come throughout work.
Giant mechanical shear causes the cytoskeleton matrix [another key structure that expands and contracts in response to phase changes] to fluidize, a phenomenon much like bodily rejuvenation in SGM’s [certain synthetic materials]. This fluidization is adopted by a sluggish scale- free restoration of mechanical properties, a phenomenon much like bodily getting older in SGMs.
Surprisingly in response to a transient stretch, the cytoskeleton fluidizes in a sample that’s common for various cell varieties. This discovering implicates mechanisms mediated not a lot by particular signaling pathways, as it’s often assumed, however relatively – as we clarify beneath – by non-specific actions of bodily forces.
Many different constructions even have the power for his or her inside gels to trigger enlargement and contraction, however not like skeletal muscle tissues, most often, this enlargement and contraction just isn’t as tightly constrained as what’s noticed inside the closely cross-linked skeletal muscle tissues.
Clean muscle tissues, in addition to contractile rings, artificial actin gels (actin is likely one of the most typical contractile proteins within the physique), and different organelles with few covalent cross hyperlinks and semi-random constructions are different examples of locations the place the physique makes use of this precept to maintain life.
Lastly, it has additionally been noticed that altering the encircling concentrations of salinity round different fibers (e.g., collagen) may cause them to increase and contract to the purpose they will generate a pressure yielding contraction much like that of a muscle fiber.
Conclusion
There have been a couple of central questions I’ve sought to handle in my exploration of liquid crystalline water. On this sequence, I sought a mechanism to elucidate the commentary in quite a few conventional medical programs that an inherent expansive pressure exists all through the physique which performs a key function in offering its vitality and that when this expansive pressure is compromised, a wide range of illnesses set in.
I agree with this perception and have seen quite a few situations the place it turned doable to acknowledge the place that life sustaining enlargement had been changed with a decent compacted house, and likewise seen strategies that sought to revive that enlargement additionally restore a affected person’s vitality.
Conversely, I consider the lack of mobility and sturdiness that accompanies getting older (and one of many largest considerations to elder sufferers) is immediately associated to the lack of liquid crystalline water we sometimes expertise with age.
On this article, I’ve tried as an instance the structural results of liquid crystalline water inside the physique, and it’s my hope that via doing so, I’ve supplied a mechanism to elucidate the place that expansive pressure originates from. Within the subsequent a part of this sequence, I clarify how water’s liquid crystalline state creates a gradient that may be harvested for power and creates the circulation life relies upon upon.
Within the article after that, I did my finest to elucidate the intertwined relationship between liquid crystalline water and zeta potential, and within the last a part of this sequence I mentioned the strategies I’ve come throughout which seem to revive both.
Every of those subjects is sort of advanced (e.g., this text was a synthesis of quite a few books and articles), however in my view nonetheless essential to dive into for unravelling the mysteries of life. In flip, it’s my honest hope the widespread awakening that has occurred in our society on account of COVID-19 can rekindle curiosity to discover unconventional topics like this.
I thank every of you for the eye you gave in making an attempt to understanding this comparatively advanced matter which is close to and pricey to my coronary heart. I sincerely hope that you can also undertake a few of its implications into your day by day life.
A Word From Dr. Mercola In regards to the Creator
A Midwestern Physician (AMD) is a board-certified doctor within the Midwest and a longtime reader of Mercola.com. I recognize his distinctive perception on a variety of subjects and I am grateful to share them. I additionally respect his need to stay nameless as he’s nonetheless on the entrance traces treating sufferers. To seek out extra of AMD’s work, make sure you try The Forgotten Aspect of Drugs on Substack.
