Saying a brand new article publication for Cardiovascular Improvements and Functions journal. Myocardial infarction (MI) triggers adversarial reworking mechanisms, thus resulting in coronary heart failure. For the reason that utility of biomaterial-based scaffolds emerged as a viable method for offering mechanical help and selling cell development, injectable hydrogels have garnered substantial consideration in MI remedy due to their minimally invasive administration by injection and diminished danger of an infection.
To completely perceive the interaction between injectable hydrogels and infarcted myocardium restore, this evaluation offers an summary of latest advances in injectable hydrogel-mediated MI remedy, together with: I) materials designs for repairing the infarcted myocardium, contemplating the pathophysiological mechanism of MI and design ideas for biomaterials in MI remedy; II) the event of injectable practical hydrogels for MI remedy, together with conductive, self-healing, drug-loaded, and stimulus-responsive hydrogels; and III) analysis progress in utilizing injectable hydrogels to revive cardiac operate in infarcted myocardium by selling neovascularization, enhancing cardiomyocyte proliferation, reducing myocardial fibrosis, and inhibiting extreme irritation.
Total, this evaluation presents the present state of injectable hydrogel analysis in MI remedy, providing beneficial info to facilitate interdisciplinary information switch and allow the event of prognostic markers for appropriate injectable supplies.
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Journal reference:
Yi, B., et al. (2024). Overview of Injectable Hydrogels for the Therapy of Myocardial Infarction. Cardiovascular Improvements and Functions. doi.org/10.15212/cvia.2024.0019.
