Hydroxychloroquine vs Ivermectin vs Quercetin: What is the Distinction? (2023 Version)

As of November 2023, there are greater than 3,000 research printed associated to the remedy and prevention of COVID-19.

If you’re nonetheless confused in regards to the suggestions made by completely different skilled teams for the COVID-19 pandemic, you have come to the appropriate place.

The variety of choices for the remedy of COVID-19 has elevated drastically in current months, thus making it sophisticated on the subject of selecting the best mixture. Usually, there are 3 broad classes of medical interventions:

1. Prevention or Prophylaxis e.g. vaccine
2. Early out-patient remedy
3. Hospital remedy

The varied therapies obtainable for various circumstances usually contain the usage of complicated applied sciences and specialised terminology, which will be overwhelming and complicated for shoppers. To realize the absolute best final result, a number of therapies and methods are usually utilized in mixture. Subsequently, it is vital to work intently along with your healthcare supplier to grasp the completely different choices obtainable and decide one of the best plan of action on your particular wants.

The medical group themselves are battling over ivermectin and hydroxychloroquine on whether or not they need to be used to deal with and forestall COVID-19. On one aspect are specialists telling you that extra analysis is required earlier than the remedy will be totally approved and confirmed. On the opposite, are specialists telling you that the potential advantages outweigh the chance and a ‘wait and do nothing’ place is just not acceptable. Confused? 

When confronted with conflicting steerage from completely different knowledgeable teams, it may be difficult to navigate by way of the various opinions. One widespread concern is that some teams could have a pre-determined narrative that they want to assist, resulting in cherry-picking of research that align with their views. This strategy can lead to biased and manipulated selections. To acquire a extra correct understanding, it’s essential to investigate scientific data comprehensively, in an up to date and non-biased method. This requires evaluating a broad vary of proof from a number of sources and punctiliously weighing the strengths and limitations of every examine, to reach at an knowledgeable resolution.

On this article, we might cowl 3 widespread therapies i.e. Hydroxychloroquine, Ivermectin and Quercetin.

Hydroxychloroquine

COVID sufferers who have been handled with hydroxychloroquine have been much less prone to die than those that weren’t, in keeping with a November 2023 examine.

Simply 0.8 p.c of sufferers at a facility in France who obtained hydroxychloroquine (HCQ) and an antibiotic died, in contrast with 4.8 p.c of sufferers who did not obtain the drug mixture, French researchers reported on Nov. 1, 2023.

The November 2023 examine got here a couple of month after researchers in Belgium reported in one other observational examine that HCQ with AZ diminished COVID-19 mortality amongst hospitalized sufferers.

Traditionally, hydroxychloroquine was found throughout efforts to synthesize alternate options to quinine as anti-malarials. Is quinine much like hydroxychloroquine? Hydroxychloroquine and quinine are each anti-malarial medicine. Nonetheless, hydroxychloroquine is just not the identical as quinine as hydroxychloroquine is an artificial drug whereas quinine is a naturally occurring compound present in cinchona bark. 

Quinine, was first acknowledged as a potent antimalarial agent tons of of years in the past. Since then, the helpful results of quinine and its extra superior artificial types, chloroquine and hydroxychloroquine, have been more and more acknowledged in a myriad of different illnesses along with malaria.

Is quercetin identical as quinine? No. Quercetin is a phytonutrient whereas quinine is a naturally occurring compound present in cinchona bark and was used as an antimalarial agent. Nonetheless, each quercetin and quinine are identified to have zinc ionophore properties i.e. they transport zinc into the cells. 

Hydroxychloroquine, developed within the Fifties from chloroquine, an previous anti-malarial drug, is registered in round 60 nations below commerce names akin to Plaquenil, Quensyl and Plaquinol.

 

Hydroxychloroquine, a much less poisonous spinoff of Chloroquine is a extensively used treatment by folks with lupus or arthritis. 

Hydroxychloroquine and COVID-19

Hydroxychloroquine (HCQ) is just not efficient when used very late with excessive dosages over a protracted interval, effectiveness improves with earlier utilization and improved dosing. Early remedy constantly reveals optimistic results. Detrimental evaluations usually ignore remedy time, usually specializing in a subset of late stage research.

Dr. Raoult and his co-authors acknowledged {that a} World Well being Group 2021 trial have discovered no advantages for HCQ towards COVID-19. However they stated that the trial, which was funded by the World Well being Group and the UK authorities, suffered from “important methodological issues,” together with excessive dosing in the course of the first 24 hours.

As of November 2023, there are greater than 350 printed proof of hydroxychloroquine for COVID-19 (c19hcq.org).

Primarily based on the database on C19Early.com (as of November 2023) beneath: 

• quercetin performs higher than hydroxychloroquine and ivermectin for prevention however 
• ivermectin and hydroxychloroquine are superior than quercetin by way of early remedy

Prevention league desk: Quercetin (93%) vs Ivermectin (85%) vs Hydroxychloroquine (33%)

Early Remedy League Desk: Hydroxychloroquine (65%) vs Ivermectin (62%) vs Quercetin (32%)

A big distinction emerges between initiating remedy early versus late. Late remedy is much less prone to be efficient when in comparison with early intervention. Nonetheless, initiating remedy early presents its personal set of challenges, as it might take a number of days to endure testing, acquire a prescription, and have it stuffed. 

Contemplating the multitude of research and the dimensions of affected person populations concerned, hydroxychloroquine continues to be one of many high selections for decreasing COVID-19 mortality (League desk beneath). If you’re contemplating stockpiling hydroxychloroquine, it’s advisable to seek the advice of with a medical physician on-line beforehand.

Credit score: C19Early.org

Do you want a prescription for hydroxychloroquine?

Sure, hydroxychloroquine is a prescription drug and also you do want it to be prescribed to you by a physician.

Associated: Discover a Physician who will prescribe Hydroxychloroquine

Ivermectin and COVID-19

Ivermectin is an anti-parasitic treatment extensively utilized in low- and middle-income nations to deal with parasitic worm infections in adults and kids. It’s been used for many years for this function by over 3.7 billion folks, and is taken into account protected and efficient. It has an growing record of indications resulting from its antiviral and anti inflammatory properties, and is included on the WHO’s Mannequin Checklist of Important Medicines.

As of November 2023, there are greater than 90 research on ivermectin and COVID-19. Take a look at the proof tracker on ivermectin and COVID-19 from c19ivermectin.com (continuously up to date).

Is ivermectin a zinc ionophore? Though there are numerous articles stating it’s however most articles don’t present scientific references to assist the declare. Now we have discovered research that confirmed that ivermectin has a possible ionophore nature: 

• Ivermectin, antiviral properties and COVID-19: a potential new mechanism of motion (Naunyn Schmiedebergs Arch Pharmacol. 2020).
• The multitargeted drug ivermectin: from an anti-parasitic agent to a repositioned most cancers drug (Am J Most cancers Res. 2018)

Ivermectin and FLCCC Protocols

The Entrance Line COVID-19 Vital Care (FLCCC) Alliance was initially shaped as a working group in the course of the early COVID-19 pandemic days in response to a number of early experiences of COVID sufferers with an inexplicably excessive want for extended mechanical air flow and an extreme loss of life fee.

Primarily based on quickly rising scientific trials proof, the FLCCC group has developed a number of protocols:

• I-PREVENT (COVID Safety), 
• I-CARE (Early at-home remedy), 
• I-RECOVER (Submit-Vaccine remedy)

Issues and Cautions:

• Ivermectin has a variety of probably severe drug-drug interactions. Please test for potential drug interplay at Ivermectin Drug Interactions – Medication.com. An important drug interactions happen with cyclosporin, tacrolimus, anti-retroviral medicine, and sure anti-fungal medicine. 
• Quercetin and ivermectin interactions? In response to Medication.com: “No interactions have been discovered between ivermectin and Quercetin. This doesn’t essentially imply no interactions exist. At all times seek the advice of your healthcare supplier.”
• Ivermectin can be lipophilic and subsequently, bioavailability is maximised on a full abdomen; or finest to be taken with meal.

Ivermectin for COVID-19: Actual-time meta evaluation

Take a look at the actual time meta-analysis on Ivermectin and COVID-19 from Ivmmeta.com (continuously up to date).

Associated: 

• Checklist of Medical doctors that can prescribe Ivermectin

• Checklist of Pharmacies that can fill Ivermectin

Quercetin and COVID-19

Are there dietary supplements much like hydroxychloroquine? Quercetin acts as a zinc ionophore (PubMed 2014), the identical mechanism of motion that hydroxychloroquine has through serving to zinc go the cell wall the place it would halt viral replication.

This zinc ionophore exercise of quercetin facilitates the transport of zinc
throughout the cell membrane. It’s identified that zinc will decelerate the
replication of coronavirus by way of inhibition of enzyme RNA polymerase (PubMed 2010). The COVID-19 is an RNA (RiboNucleicAcid) virus and requires the RNA polymerase to copy. Do take word that the examine publication was a 2010
publication and is referring to a distinct coronavirus as in comparison with the
newest coronavirus (COVID-19); although each are from the identical household of
coronaviruses.

A overview printed in The Sage Journal (Dec 2020), summarizes the antiviral significance of quercetin and proposes a potential technique for the efficient utilization of pure polyphenols in our every day food plan for the prevention of viral an infection.

An animal examine printed within the Nature (Aug 2012), concluded that quercetin has anti-oxidant, anti-inflammatory and anti-fibrotic (anti-scarring) properties. One other examine (JCI Could 2012) on rutin (quercetin molecule sure to a sugar molecule referred to as rutinose), generally present in fruit and veggies and offered over-the-counter as a dietary complement, has been proven to inhibit the formation of blood clots in an animal mannequin of thrombosis.

As of August 2023, there have been greater than 10 printed research of quercetin towards COVID-19. For the record of research, take a look at c19quercetin.com.

Quercetin, Zinc and Vitamin C

By the way, ascorbic acid (vitamin C) and the bioflavonoid quercetin
(initially labeled vitamin P) have been each found by the identical scientist
— Nobel prize winner Albert Szent-Györgyi. Quercetin and vitamin C additionally act as an antiviral drug, successfully
inactivating viruses. 

There’s proof that vitamin C and quercetin co-administration
exerts a synergistic antiviral motion resulting from overlapping antiviral and
immuno-modulatory properties and the capability of ascorbate to recycle
quercetin, growing its efficacy.

Quercetin can be a part of the FLCCC I-MASK+ protocol and Zelenko protocol for COVID-19.

For up to date prevention protocol (COVID-19 optimistic), please take a look at FLCCC I-MASK+ protocol.

Associated: 

• Checklist of Medical doctors that can prescribe early remedy
• Greatest Pulse Oximeter
• Greatest Mouthwashes for COVID-19

Quercetin works finest when taken with vitamin C and Bromelain, as vitamin C helps activate it and bromelain helps with the absorption. On this examine (PubMed), Bromelain additionally has anti-viral property towards COVID-19 virus and anti-clotting property, and subsequently could also be helpful towards COVID-19.

Warning: Quercetin has one average drug interplay with warfarin. Don’t take quercetin with out medical recommendation if you’re utilizing warfarin.

Ivermectin vs Hydroxychloroquine vs Quercetin

Scientific proof so far has reported promising outcomes (see above) for
Ivermectin in prevention, early remedy in addition to late remedy for
COVID-19. Whereas each Ivermectin and Hydroxychloroquine could be helpful for
early remedy, Ivermectin has a broader potential profit i.e. prevention,
early remedy in addition to late remedy / hospital remedy. An vital to notice is that each ivermectin and hydroxychloroquine carry out higher when given early (inside first 3 – 5 days of signs) versus late remedy.

Hydroxychloroquine and Quercetin are each zinc ionophores i.e. they
transport zinc into the cells. 

Nonetheless, quercetin is much less potent than HCQ (hydroxychloroquine) as a zinc
transporter, and it doesn’t attain excessive concentrations in lung cells that
HCQ does. Quercetin could assist cut back threat of viral sickness if you’re
mainly wholesome. However it’s not potent sufficient to exchange HCQ for
remedy of COVID upon getting signs, and it doesn’t adequately get
into lung tissue.

That stated, should you merely can not get hydroxychloroquine or ivermectin,
quercetin is a viable stand-in. Quercetin works finest when taken with
vitamin C and Bromelain, as vitamin C helps activate it and bromelain
helps with the absorption. Don’t forget to mix it with zinc.

Is quercetin a safer various to hydroxychloroquine? Though ivermectin and hydroxychloroquine are comparatively protected medicine, they’re nonetheless artificial chemical substances that may have uncomfortable side effects. Quercetin and Vitamin D, C, Zinc are vitamins that your physique require for optimum well being. Vitamins are safer alternate options particularly in case your threat is low e.g. age beneath 50 and no different continual sickness. 

Different alternate options akin to Betadine mouthwash and Betadine nasal spray are over-the-counter merchandise that you possibly can get simply out of your nearest pharmacy. Importantly, you might want to begin the remedy early. There is a massive distinction by way of final result relying on how early your remedy is. 

Focus on along with your physician on the profit vs threat for every remedy. If you’re on a number of drugs, pay attention to supplement-drug interactions which may improve the probabilities of opposed results.

Hydroxychloroquine, Ivermectin, Quercetin and FLCCC Protocols

Hydroxychloroquine, ivermectin and quercetin are all a part of the newest FLCCC I-PREVENT and I-CARE early remedy protocols.

For up to date prevention protocol and remedy protocol (COVID-19 optimistic), please take a look at FLCCC’s I-PREVENT and I-CARE protocols.

Different Early Remedy Choices

For an up-to-date overview of all printed research on early remedy and prevention of COVID-19, we advocate visiting C19Early. 

Abstract

Though ivermectin and hydroxychloroquine are comparatively
protected medicine, they’re nonetheless artificial chemical substances that may have uncomfortable side effects.
Quercetin is a phytonutrient that can profit your physique for optimum
well being. 

For a listing of confirmed advantages of quercetin (by class), take a look at
advantages of quercetin.

Vitamins are safer alternate options particularly in case your threat is low e.g. age
beneath 50 and no different continual sickness. Focus on along with your physician on the
profit vs threat for every remedy. If you’re on a number of drugs, be
conscious of supplement-drug interactions which may improve the probabilities
of opposed results.

The vital key takeaway is ‘early’ remedy. That stated you need to by no means try and self medicate
with out the steerage of a licensed medical supplier. If you’re not a medical
physician, you might be prone to discover the above data overwhelming. The goal of
this text is to empower you with a greater understanding of the choices
obtainable and to debate the choices along with your medical physician.

Associated: Greatest Quercetin and Zinc Dietary supplements

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Z-Stack Complement

In an effort to make it simpler for sufferers, Dr Zelenko has developed an oral complement that incorporates all 4 key substances: vitamin C, quercetin, vitamin D3 and zinc. It’s known as ‘Z-Stack Complement’. 

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The price of the Z-STACK vitamin cocktail is $55 per bottle for a one month provide. 

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